![]() Overall, our study identifies a GSL signature that inhibits immune recognition and represents a potential therapeutic target in cancer, infection, and autoimmunity. We show that the immunomodulatory effect could be reversed through GSL synthesis inhibition using clinically approved drugs. Furthermore, a disturbed SPP元-B3GNT5 pathway in glioma correlated with decreased patient survival. REPERTOIRE meaning: 1 : all the plays, songs, dances, etc., that a performer or group of performers knows and can perform 2 : all the things that a person. These GSLs sterically impeded antibody and receptor interactions with HLA-I and diminished CD8+ T cell activation. We show that absence of the protease SPP元 augmented B3GNT5 enzyme activity, resulting in upregulation of surface neolacto-series GSLs. ![]() Using iterative genome-wide screens, we uncovered that the cell surface glycosphingolipid (GSL) repertoire determines effective HLA-I antigen presentation. A collection of music that a student has learned and is prepared. Because options for restoring HLA-I antigen presentation are limited, we aimed to identify druggable HLA-I pathway targets. Definition of repertoire in English English dictionary A set of skills possessed by a person. This process is often hijacked by tumors and pathogens for immune evasion. Florian Rubelt, Volker Sievert, Florian Knaust. Show more HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8+ T cells. Onset of Immune Senescence Defined by Unbiased Pyrosequencing of Human Immunoglobulin mRNA Repertoires. Overall, our study identifies a GSL signature that. We show that the immunomodulatory effect could be reversed through GSL synthesis inhibition using clinically approved drugs. In terms of anthropology and psychology, the full range of behavior of an animal or a person, the behavior like sitting. This dictionary is a project of the Research Net and its collaborators that collects terms used in the research of rhetoric from an anthropological. Furthermore, a disturbed SPP元-B3GNT5 pathway in glioma correlated with decreased patient survival. ![]() Because options for restoring HLA-I antigen presentation are limited, we aimed to identify druggable HLA-I pathway targets. The SPP元-defined glycosphingolipid repertoire orchestrates HLA class I-mediated immune responses Article / Letter to editor HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8+ T cells.
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